Peptide Atlas · Excipient

EDTA-2Na

Edetate disodium (EDTA) is a chelating agent; in a monoclonal antibody formulation it mitigated both polysorbate 80 loss and methionine oxidation, proposed to act by chelating calcium and so reducing lipase activity.

preclinical

provisional
PubChem 44120005
2 citations
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Disodium EDTA dihydrate
EDTA

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Edetate disodium as a polysorbate degradation and antibody oxidation stabilizer standing
- resolved
Edetate Disodium as a Polysorbate Degradation and Monoclonal Antibody Oxidation Stabilizer.
Yarbrough M, Hodge T, Menard D, Jerome R, Ryczek J, Moore D, Baldus P, Warne N, Ohtake S
pmid 30502482
- preclinical
  Claim: Residue-specific impact of EDTA and methionine on protein oxidation standing
- resolved
Residue-Specific Impact of EDTA and Methionine on Protein Oxidation in Biotherapeutics Formulations Using an Integrated Biotherapeutics Drug Product Development Workflow.
Thakkar SV, Rodrigues D, Zhai B, Banton D, Somani S, Javidi A, Mahan A, Ember S, DeGrazio D, Ganguly S, Amin K, Nanda H
pmid 36130676

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