Peptide Atlas · Peptide

FOXO4-DRI

FOXO4-DRI is a peptide designed to disrupt the interaction of FOXO4 with p53, which in senescent cells causes p53 nuclear exclusion and cell-intrinsic apoptosis.

preclinical

provisional
PubChem 167312269
2 citations
0 discussions
0 followers
FOX04-DRI
FOXO4-D-Retro-Inverso
Senolytic peptide

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for FOXO4-DRI. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Targeted apoptosis of senescent cells in mice	preclinical	pmid 28340339
Solution NMR structures of p53 with FOXO4 and FOXO4-DRI	preclinical	pmid 40593617

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.