Peptide Atlas · Peptide

FOXO4-DRI

FOXO4-DRI is a peptide designed to disrupt the interaction of FOXO4 with p53, which in senescent cells causes p53 nuclear exclusion and cell-intrinsic apoptosis.

preclinical

provisional
PubChem 167312269
2 citations
0 discussions
0 followers
FOX04-DRI
FOXO4-D-Retro-Inverso
Senolytic peptide

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Targeted apoptosis of senescent cells in mice standing
- resolved
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ
pmid 28340339
- preclinical
  Claim: Solution NMR structures of p53 with FOXO4 and FOXO4-DRI standing
- resolved
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T
pmid 40593617

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Negative findings

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