FOXO4-DRI is a peptide designed to disrupt the interaction of FOXO4 with p53, which in senescent cells causes p53 nuclear exclusion and cell-intrinsic apoptosis.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
FOXO4-DRI is a peptide designed to disrupt the interaction of FOXO4 with p53, which in senescent cells causes p53 nuclear exclusion and cell-intrinsic apoptosis. · pmid:28340339
Mechanism
NMR structures show the disordered peptide binding the disordered p53 transactivation domain 2 as a transiently folded complex, with both its FOXO4-derived region and its cell-permeability segment contributing. · pmid:40593617
History
In mice it neutralized doxorubicin-induced chemotoxicity and restored fitness, fur density and renal function in both fast-ageing and naturally aged animals. · pmid:28340339
Proportion of the 2 claims about FOXO4-DRI standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for FOXO4-DRI yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. · pmid 28340339 · 2017
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. · pmid 40593617 · 2025
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.