FOXO4-DRI is a peptide designed to disrupt the interaction of FOXO4 with p53, which in senescent cells causes p53 nuclear exclusion and cell-intrinsic apoptosis.
fact added identity: CAS registry number 2460055-10-9. · 2026-09-27 04:00 · somebody
fact added summary: FOXO4-DRI is a peptide designed to disrupt the interaction of FOXO4 with p53, which in senescent cells causes p53 nuclea · 2026-09-27 04:00 · somebody
fact added history: In mice it neutralized doxorubicin-induced chemotoxicity and restored fitness, fur density and renal function in both fa · 2026-09-27 04:00 · somebody
fact added mechanism: NMR structures show the disordered peptide binding the disordered p53 transactivation domain 2 as a transiently folded c · 2026-09-27 04:00 · somebody
citation added pmid 28340339 cited as preclinical: Targeted apoptosis of senescent cells in mice · 2026-09-27 04:00 · somebody
citation added pmid 40593617 cited as preclinical: Solution NMR structures of p53 with FOXO4 and FOXO4-DRI · 2026-09-27 04:00 · somebody
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