GHK (glycyl-L-histidyl-L-lysine) is a human copper-binding tripeptide whose levels decline with age; it has been reported to support wound healing and tissue repair and to increase collagen and decorin.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
GHK (glycyl-L-histidyl-L-lysine) is a human copper-binding tripeptide whose levels decline with age; it has been reported to support wound healing and tissue repair and to increase collagen and decorin. · pmid:28212278
Mechanism
In a Connectivity Map analysis of lung tissue from smokers with COPD, GHK was identified as reversing the gene-expression signature of emphysematous destruction, and in human fibroblasts it reproduced TGF-beta-induced expression patterns. · pmid:22937864
Proportion of the 2 claims about GHK (free tripeptide, no copper) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for GHK (free tripeptide, no copper) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. · pmid 22937864 · 2012
The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline. · pmid 28212278 · 2017
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.