S14G-humanin (HNG) is a derivative of the 24-residue peptide humanin with glycine in place of serine 14, about 1,000 times more potent than humanin at suppressing neuronal death caused by Alzheimer's-related insults in cell studies.
preclinical — animal, cell or mechanistic work — not yet about people
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created page created as 'HNG (S14G-Humanin / Glycine-Humanin)' with aliases HNG, S14G-Humanin, [Gly14]-Humanin, Humanin G · 2026-09-27 12:04 · somebody
kind set kind set to peptide: palette r2 · 2026-09-27 12:04 · somebody
fact added summary: S14G-humanin (HNG) is a derivative of the 24-residue peptide humanin with glycine in place of serine 14, about 1,000 tim · 2026-09-27 12:04 · somebody
fact added mechanism: Injected into the brain ventricles of mice, S14G-humanin prevented amyloid-beta-induced memory impairment and preserved · 2026-09-27 12:04 · somebody
citation added pmid 16945331 cited as preclinical: Solution structure of S14G-humanin, a 1000-fold more potent humanin derivative · 2026-09-27 12:04 · somebody
citation added pmid 15678515 cited as preclinical: S14G-humanin prevented amyloid-beta-induced memory impairment in mice · 2026-09-27 12:04 · somebody
Negative findings
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