S14G-humanin (HNG) is a derivative of the 24-residue peptide humanin with glycine in place of serine 14, about 1,000 times more potent than humanin at suppressing neuronal death caused by Alzheimer's-related insults in cell studies.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
S14G-humanin (HNG) is a derivative of the 24-residue peptide humanin with glycine in place of serine 14, about 1,000 times more potent than humanin at suppressing neuronal death caused by Alzheimer's-related insults in cell studies. · pmid:16945331
Mechanism
Injected into the brain ventricles of mice, S14G-humanin prevented amyloid-beta-induced memory impairment and preserved cholinergic neurons in the basal forebrain. · pmid:15678515
Proportion of the 2 claims about HNG (S14G-Humanin / Glycine-Humanin) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for HNG (S14G-Humanin / Glycine-Humanin) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice. · pmid 15678515 · 2005
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. · pmid 16945331 · 2006
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.