Peptide Atlas · Peptide

HNG (S14G-Humanin / Glycine-Humanin)

S14G-humanin (HNG) is a derivative of the 24-residue peptide humanin with glycine in place of serine 14, about 1,000 times more potent than humanin at suppressing neuronal death caused by Alzheimer's-related insults in cell studies.

preclinical

provisional
PubChem 155887372
2 citations
0 discussions
0 followers
HNG
Humanin G
S14G-Humanin
[Gly14]-Humanin

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: S14G-humanin prevented amyloid-beta-induced memory impairment in mice standing
- resolved
A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice.
Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I
pmid 15678515
- preclinical
  Claim: Solution structure of S14G-humanin, a 1000-fold more potent humanin derivative standing
- resolved
Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.
Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M
pmid 16945331

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Negative findings

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