Arginine is widely used in protein production as an aggregation suppressor rather than a protein stabilizer, acting by weakening protein-protein interactions.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Arginine is widely used in protein production as an aggregation suppressor rather than a protein stabilizer, acting by weakening protein-protein interactions. · pmid:16522173
Mechanism
It barely changed protein melting temperature but increased the reversibility of thermal melting and reduced aggregation under thermal stress. · pmid:12705899
Proportion of the 2 claims about L-Arginine HCl standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for L-Arginine HCl yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation. · pmid 12705899 · 2003
Review: Why is arginine effective in suppressing aggregation? · pmid 16522173 · 2005
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.