Peptide Atlas · Small molecule

L-Methionine

Free L-methionine is used as an antioxidant in protein formulations; above 20 mM it outperformed conventional antioxidants in limiting oxidation and aggregation of a high-concentration antibody.

established

provisional
PubChem 6137
4 citations
0 discussions
0 followers
(S)-2-amino-4-(methylthio)butanoic acid
M
Met
Methionine

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 4 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for L-Methionine. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Methionine's roles in transsulfuration and methyl donation, and human methionine nutrition	established	pmid 33000159
Dietary methionine restriction changed tumour one-carbon metabolism and therapy response in mice	preclinical	pmid 31367041
Residue-specific impact of EDTA and methionine on protein oxidation	preclinical	pmid 36130676
High-concentration L-methionine as an antioxidant in antibody formulations	preclinical	pmid 40978010

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.