Free L-methionine is used as an antioxidant in protein formulations; above 20 mM it outperformed conventional antioxidants in limiting oxidation and aggregation of a high-concentration antibody.
established — replicated in humans, or settled by a regulator
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alias added now also answers to 'Met' · 2026-09-27 12:04 · somebody
alias added now also answers to 'M' · 2026-09-27 12:04 · somebody
alias added now also answers to '(S)-2-amino-4-(methylthio)butanoic acid' · 2026-09-27 12:04 · somebody
kind set kind set to small_molecule: palette r2 · 2026-09-27 12:04 · somebody
fact added summary: Methionine is a nutritionally indispensable, sulfur-containing amino acid: it supplies cysteine, and so glutathione, thr · 2026-09-27 12:04 · somebody
fact added mechanism: Restricting dietary methionine altered one-carbon metabolism and improved responses to chemotherapy or radiation in mous · 2026-09-27 12:04 · somebody
citation added pmid 33000159 cited as established: Methionine's roles in transsulfuration and methyl donation, and human methionine nutrition · 2026-09-27 12:04 · somebody
citation added pmid 31367041 cited as preclinical: Dietary methionine restriction changed tumour one-carbon metabolism and therapy response in mice · 2026-09-27 12:04 · somebody
created page created as 'L-Methionine' with aliases Methionine · 2026-09-27 04:00 · somebody
citation added pmid 36130676 cited as preclinical: Residue-specific impact of EDTA and methionine on protein oxidation · 2026-09-27 04:00 · somebody
kind set kind set to excipient: palette r1 · 2026-09-27 04:00 · somebody
fact added summary: Free L-methionine is used as an antioxidant in protein formulations; above 20 mM it outperformed conventional antioxidan · 2026-09-27 04:00 · somebody
fact added mechanism: Its effect on oxidation differs by residue: a study of three antibody proteins mapped residue-specific protection by met · 2026-09-27 04:00 · somebody
citation added pmid 40978010 cited as preclinical: High-concentration L-methionine as an antioxidant in antibody formulations · 2026-09-27 04:00 · somebody
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