L-Methionine

• • established
    Claim: Methionine's roles in transsulfuration and methyl donation, and human methionine nutrition standing
  • resolved

  Methionine Nutrition and Metabolism: Insights from Animal Studies to Inform Human Nutrition.

  Elango R

  pmid 33000159

• • preclinical
    Claim: Dietary methionine restriction changed tumour one-carbon metabolism and therapy response in mice standing
  • resolved

  Dietary methionine influences therapy in mouse cancer models and alters human metabolism.

  Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, Nichenametla SN, Locasale JW

  pmid 31367041

• • preclinical
    Claim: Residue-specific impact of EDTA and methionine on protein oxidation standing
  • resolved

  Residue-Specific Impact of EDTA and Methionine on Protein Oxidation in Biotherapeutics Formulations Using an Integrated Biotherapeutics Drug Product Development Workflow.

  Thakkar SV, Rodrigues D, Zhai B, Banton D, Somani S, Javidi A, Mahan A, Ember S, DeGrazio D, Ganguly S, Amin K, Nanda H

  pmid 36130676

• • preclinical
    Claim: High-concentration L-methionine as an antioxidant in antibody formulations standing
  • resolved

  High-concentration L-methionine as a potent antioxidant for oxidation resistance and stability enhancement in high-concentration antibody therapeutics.

  Wang X, Zhang X, Xu J, Xu S, Huang K, Ni Q, Shen X, Zhang W, Liu T, Dong T, Mao D, Zheng C, Yu W, Guo Q, Li Z, Cao J, Han F, Ji L, Qian W, Hou S, Li J, Sun Z, Dai J, Guo Y, Zhang D, Guo H

  pmid 40978010

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.