5-methyltetrahydrofolate (5-MTHF) is the main naturally circulating folate; unlike synthetic folic acid, it is well absorbed when stomach pH is altered and does not depend on the MTHFR enzyme, so it bypasses that genetic defect.
established — replicated in humans, or settled by a regulator
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created page created as 'L-Methylfolate (5-MTHF, active folate)' with aliases 5-MTHF, L-5-methyltetrahydrofolate, levomefolic acid, active folate, Metafolin/Quatrefolic (salt brands), vitamin B9 active form · 2026-09-27 12:04 · somebody
kind set kind set to vitamin: palette r2 · 2026-09-27 12:04 · somebody
fact added summary: 5-methyltetrahydrofolate (5-MTHF) is the main naturally circulating folate; unlike synthetic folic acid, it is well abso · 2026-09-27 12:04 · somebody
fact added mechanism: Infused into the forearm of 10 patients with familial hypercholesterolaemia, 5-MTHF restored impaired endothelium-depend · 2026-09-27 12:04 · somebody
citation added pmid 24494987 cited as established: Review: folate, folic acid and 5-MTHF differ in absorption and metabolism · 2026-09-27 12:04 · somebody
citation added pmid 9462523 cited as emerging: 5-MTHF restored endothelial function in familial hypercholesterolaemia (n=10) · 2026-09-27 12:04 · somebody
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