Peptide Atlas · Vitamin

L-Methylfolate (5-MTHF, active folate)

5-methyltetrahydrofolate (5-MTHF) is the main naturally circulating folate; unlike synthetic folic acid, it is well absorbed when stomach pH is altered and does not depend on the MTHFR enzyme, so it bypasses that genetic defect.

established

provisional
PubChem 135398561
2 citations
0 discussions
0 followers
5-MTHF
L-5-methyltetrahydrofolate
Metafolin/Quatrefolic (salt brands)
active folate
levomefolic acid
vitamin B9 active form

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: 5-MTHF restored endothelial function in familial hypercholesterolaemia (n=10) standing
- resolved
5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ
pmid 9462523
- established
  Claim: Review: folate, folic acid and 5-MTHF differ in absorption and metabolism standing
- resolved
Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.
Scaglione F, Panzavolta G
pmid 24494987

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.