Peptide Atlas · Vitamin

L-Methylfolate (5-MTHF, active folate)

5-methyltetrahydrofolate (5-MTHF) is the main naturally circulating folate; unlike synthetic folic acid, it is well absorbed when stomach pH is altered and does not depend on the MTHFR enzyme, so it bypasses that genetic defect.

established

provisional
PubChem 135398561
2 citations
0 discussions
0 followers
5-MTHF
L-5-methyltetrahydrofolate
Metafolin/Quatrefolic (salt brands)
active folate
levomefolic acid
vitamin B9 active form

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for L-Methylfolate (5-MTHF, active folate). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
5-MTHF restored endothelial function in familial hypercholesterolaemia (n=10)	emerging	pmid 9462523
Review: folate, folic acid and 5-MTHF differ in absorption and metabolism	established	pmid 24494987

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.