Peptide Atlas · Peptide

Leuprolide (Leuprorelin)

Leuprorelin (leuprolide acetate) is a GnRH analogue that causes a brief initial rise in gonadotrophins and then, with continued use, pituitary desensitisation and suppressed sex hormones; it is used in advanced prostate cancer, endometriosis and central precocious puberty.

established

provisional
PubChem 657181
2 citations
0 discussions
0 followers
D-Leu6-LHRH-NHEt
Eligard
Leuprolide acetate
Leuprorelin
Lupron

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Leuprolide (Leuprorelin). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Leuprorelin missed its primary endpoint in spinal and bulbar muscular atrophy (JASMITT RCT)	established	pmid 20691641
Review of leuprorelin's pharmacology and uses in sex-hormone-related disorders	established	pmid 7533699

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.