Peptide Atlas · Peptide

Leuprolide (Leuprorelin)

Leuprorelin (leuprolide acetate) is a GnRH analogue that causes a brief initial rise in gonadotrophins and then, with continued use, pituitary desensitisation and suppressed sex hormones; it is used in advanced prostate cancer, endometriosis and central precocious puberty.

established

provisional
PubChem 657181
2 citations
0 discussions
0 followers
D-Leu6-LHRH-NHEt
Eligard
Leuprolide acetate
Leuprorelin
Lupron

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- established
  Claim: Leuprorelin missed its primary endpoint in spinal and bulbar muscular atrophy (JASMITT RCT) standing
- resolved
Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial.
Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima M, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, Sobue G, Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group
pmid 20691641
- established
  Claim: Review of leuprorelin's pharmacology and uses in sex-hormone-related disorders standing
- resolved
Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders.
Plosker GL, Brogden RN
pmid 7533699

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Negative findings

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