Peptide Atlas · Vitamin

Levoleucovorin / Folinic acid (calcium folinate, reduced folate B9)

Levoleucovorin is the active isomer of leucovorin (folinic acid); in gastrointestinal cancers treated with 5-fluorouracil, randomized trials found similar efficacy and tolerability with levoleucovorin and the racemic form.

established

provisional
PubChem 135500522
2 citations
0 discussions
0 followers
5-formyltetrahydrofolate
Calcium folinate
Citrovorum factor
Folinic acid
Leucovorin calcium
Levoleucovorin calcium

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Levoleucovorin / Folinic acid (calcium folinate, reduced folate B9). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Meta-analysis: folate receptor autoantibodies and leucovorin treatment in autism	emerging	pmid 34834493
Levoleucovorin performs like racemic leucovorin with 5-FU (literature review)	established	pmid 19822510

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.