Peptide Atlas · Vitamin

Levoleucovorin / Folinic acid (calcium folinate, reduced folate B9)

Levoleucovorin is the active isomer of leucovorin (folinic acid); in gastrointestinal cancers treated with 5-fluorouracil, randomized trials found similar efficacy and tolerability with levoleucovorin and the racemic form.

established

provisional
PubChem 135500522
2 citations
0 discussions
0 followers
5-formyltetrahydrofolate
Calcium folinate
Citrovorum factor
Folinic acid
Leucovorin calcium
Levoleucovorin calcium

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

created page created as 'Levoleucovorin / Folinic acid (calcium folinate, reduced folate B9)' with aliases Folinic acid, Leucovorin calcium, Calcium folinate, Levoleucovorin calcium, 5-formyltetrahydrofolate, Citrovorum factor · 2026-09-27 12:04 · somebody
kind set kind set to vitamin: palette r2 · 2026-09-27 12:04 · somebody
fact added identity: PubChem CID 135500522: Levoleucovorin Calcium, C20H21CaN7O7, 511.5 g/mol. · 2026-09-27 12:04 · somebody
fact added identity: CAS registry number 80433-71-2. · 2026-09-27 12:04 · somebody
fact added identity: IUPAC name: calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]p · 2026-09-27 12:04 · somebody
fact added summary: Levoleucovorin is the active isomer of leucovorin (folinic acid); in gastrointestinal cancers treated with 5-fluorouraci · 2026-09-27 12:04 · somebody
fact added summary: Cerebral folate deficiency, often caused by autoantibodies to the folate receptor alpha, is treated with d,l-leucovorin; · 2026-09-27 12:04 · somebody
citation added pmid 19822510 cited as established: Levoleucovorin performs like racemic leucovorin with 5-FU (literature review) · 2026-09-27 12:04 · somebody
citation added pmid 34834493 cited as emerging: Meta-analysis: folate receptor autoantibodies and leucovorin treatment in autism · 2026-09-27 12:04 · somebody

Negative findings

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