Levoleucovorin / Folinic acid (calcium folinate, reduced folate B9)

Summary

Levoleucovorin is the active isomer of leucovorin (folinic acid); in gastrointestinal cancers treated with 5-fluorouracil, randomized trials found similar efficacy and tolerability with levoleucovorin and the racemic form. · pmid:19822510

Cerebral folate deficiency, often caused by autoantibodies to the folate receptor alpha, is treated with d,l-leucovorin; a meta-analysis in autism spectrum disorder reported improvements in communication and other symptoms with leucovorin. · pmid:34834493

Identity

PubChem CID 135500522: Levoleucovorin Calcium, C20H21CaN7O7, 511.5 g/mol. · pubchem:135500522

CAS registry number 80433-71-2. · pubchem:135500522

IUPAC name: calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate. · pubchem:135500522

Where the evidence actually sits

Proportion of the 2 claims about Levoleucovorin / Folinic acid (calcium folinate, reduced folate B9) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Levoleucovorin / Folinic acid (calcium folinate, reduced folate B9) yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Is levoleucovorin an alternative to racemic leucovorin? A literature review. · pmid 19822510 · 2009
3. Observational evidence · resolved human data at the emerging tier: thin, or contested
   • Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis. · pmid 34834493 · 2021
4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.