Lidocaine HCl

Summary

Lidocaine is a local anaesthetic; its solutions are acidic and cause pain on infiltration into the skin. · pmid:16384767

History

In a randomized study of 100 patients, adding sodium bicarbonate to lidocaine significantly reduced pain during cannulation. · pmid:2174653

Identity

PubChem CID 16219577: Lidocaine hydrochloride monohydrate, C14H25ClN2O2, 288.81 g/mol. · pubchem:16219577

CAS registry number 6108-05-0. · pubchem:16219577

IUPAC name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrate;hydrochloride. · pubchem:16219577

Where the evidence actually sits

Proportion of the 2 claims about Lidocaine HCl standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Lidocaine HCl yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier
   • Decreasing the pain of local anesthesia: a prospective, double-blind comparison of buffered, premixed 1% lidocaine with epinephrine versus 1% lidocaine freshly mixed with epinephrine. · pmid 16384767 · 2006
   • pH-adjustment and discomfort caused by the intradermal injection of lignocaine. · pmid 2174653 · 1990
3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work

   nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.