Mitochondrial open reading frame of the 12S rRNA-c: a sixteen-amino-acid peptide encoded inside mitochondrial DNA rather than the nucleus - a peptide the mitochondrion writes itself.
fact added identity: CAS registry number 1627580-64-6. · 2026-09-27 04:00 · somebody
fact added mechanism: Under metabolic stress MOTS-c translocates to the nucleus in an AMPK-dependent manner and regulates nuclear genes, inclu · 2026-09-27 04:00 · somebody
fact added history: It enhanced physical performance in young, middle-aged and old mice, and in humans exercise induced MOTS-c expression in · 2026-09-27 04:00 · somebody
citation added pmid 29983246 cited as preclinical: MOTS-c translocates to the nucleus to regulate nuclear gene expression under metabolic stress · 2026-09-27 04:00 · somebody
citation added pmid 33473109 cited as preclinical: MOTS-c is an exercise-induced regulator of age-dependent physical decline · 2026-09-27 04:00 · somebody
citation added pmid 39321430 cited as preclinical: Suppresses ovarian cancer progression via a USP7/LARS1 axis · 2026-09-23 04:19 · somebody
citation added pmid 34798268 cited as preclinical: Relieves hyperglycaemia and insulin resistance in gestational diabetes models · 2026-09-23 04:19 · somebody
citation added pmid 37200834 cited as emerging: Role in bone metabolism · 2026-09-23 04:19 · somebody
citation added pmid 36233287 cited as emerging: Relevance to human ageing and age-related disease · 2026-09-23 04:19 · somebody
created page created as 'MOTS-c' with aliases Mitochondrial ORF of the 12S rRNA-c, MOTSc · 2026-09-23 04:19 · somebody
question added Which assays actually distinguish MOTS-c from its fragments? · 2026-09-23 04:19 · somebody
question added Is there any human pharmacokinetic dataset at all? · 2026-09-23 04:19 · somebody
question added Are exercise-associated changes in circulating MOTS-c a cause or a consequence? · 2026-09-23 04:19 · somebody
fact added summary: Mitochondrial open reading frame of the 12S rRNA-c: a sixteen-amino-acid peptide encoded inside mitochondrial DNA rather · 2026-09-23 04:19 · somebody
fact added classification: Mitochondrial-derived peptide (MDP): a short-ORF product of the mitochondrial 12S rRNA locus. · 2026-09-23 04:19 · somebody
fact added history: First described in 2015 (Lee C et al., Cell Metab), as a mitochondrial signal regulating insulin sensitivity and metabol · 2026-09-23 04:19 · somebody
fact added mechanism: Reported to modulate the folate cycle and AICAR-dependent AMPK activation, with skeletal muscle the apparent principal s · 2026-09-23 04:19 · somebody
citation added pmid 25738459 cited as established: Encoded by a short ORF within the mitochondrial 12S rRNA; 16 amino acids · 2026-09-23 04:19 · somebody
citation added pmid 25738459 cited as established: Regulates insulin sensitivity and metabolic homeostasis; skeletal muscle the apparent primary target · 2026-09-23 04:19 · somebody
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