Peptide Atlas · Peptide

MOTS-c

Mitochondrial open reading frame of the 12S rRNA-c: a sixteen-amino-acid peptide encoded inside mitochondrial DNA rather than the nucleus - a peptide the mitochondrion writes itself.

established

provisional
16 aa
UniProt A0A0C5B5G6
PubChem 146675088
8 citations
0 discussions
0 followers
Mitochondrial ORF of the 12S rRNA-c

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 8 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: Relevance to human ageing and age-related disease standing
- resolved
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC
pmid 36233287
- emerging
  Claim: Role in bone metabolism standing
- resolved
Role of MOTS-c in the regulation of bone metabolism.
Yi X, Hu G, Yang Y, Li J, Jin J, Chang B
pmid 37200834
- established
  Claim: Encoded by a short ORF within the mitochondrial 12S rRNA; 16 amino acids standing
  Claim: Regulates insulin sensitivity and metabolic homeostasis; skeletal muscle the apparent primary target standing
- resolved
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P
pmid 25738459
- established
  Claim: Encoded by a short ORF within the mitochondrial 12S rRNA; 16 amino acids standing
  Claim: Regulates insulin sensitivity and metabolic homeostasis; skeletal muscle the apparent primary target standing
- resolved
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P
pmid 25738459
- preclinical
  Claim: MOTS-c translocates to the nucleus to regulate nuclear gene expression under metabolic stress standing
- resolved
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.
Kim KH, Son JM, Benayoun BA, Lee C
pmid 29983246
- preclinical
  Claim: MOTS-c is an exercise-induced regulator of age-dependent physical decline standing
- resolved
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.
Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C
pmid 33473109
- preclinical
  Claim: Relieves hyperglycaemia and insulin resistance in gestational diabetes models standing
- resolved
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.
Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X
pmid 34798268
- preclinical
  Claim: Suppresses ovarian cancer progression via a USP7/LARS1 axis standing
- resolved
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.
Yin Y, Li Y, Ma B, Ren C, Zhao S, Li J, Gong Y, Yang H, Li J
pmid 39321430

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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