N-acetylcysteine is the antidote for acetaminophen (paracetamol) overdose: in a multicenter study of 2,540 patients treated orally, liver injury was least when treatment began within 8 to 10 hours of ingestion, and efficacy fell with further delay.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
N-acetylcysteine is the antidote for acetaminophen (paracetamol) overdose: in a multicenter study of 2,540 patients treated orally, liver injury was least when treatment began within 8 to 10 hours of ingestion, and efficacy fell with further delay. · pmid:3059186
A systematic review found favourable trial evidence for N-acetylcysteine in several psychiatric and neurological disorders, and called for larger controlled trials. · pmid:25957927
Proportion of the 2 claims about N-Acetylcysteine (NAC) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for N-Acetylcysteine (NAC) yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). · pmid 3059186 · 1988
Observational evidence· resolved human data at the emerging tier: thin, or contested
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. · pmid 25957927 · 2015
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.