Peptide Atlas · Small molecule

N-Acetylcysteine (NAC)

N-acetylcysteine is the antidote for acetaminophen (paracetamol) overdose: in a multicenter study of 2,540 patients treated orally, liver injury was least when treatment began within 8 to 10 hours of ingestion, and efficacy fell with further delay.

established

provisional
PubChem 12035
2 citations
0 discussions
0 followers
N-acetyl-3-mercapto-L-alanine
N-acetyl-L-cysteine
NAC
acetylcysteine

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: Systematic review of N-acetylcysteine trials in psychiatry and neurology standing
- resolved
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
pmid 25957927
- established
  Claim: Oral N-acetylcysteine protects against acetaminophen hepatotoxicity when started early standing
- resolved
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985).
Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH
pmid 3059186

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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