Peptide Atlas · Vitamin

Pyridoxine hydrochloride

High daily doses of pyridoxine (vitamin B6) caused ataxia and severe sensory neuropathy in seven adults, all of whom improved after stopping it.

established

provisional
PubChem 6019
2 citations
0 discussions
0 followers
Adermine hydrochloride
Pyridoxine HCl
Pyridoxol hydrochloride
Vitamin B6 hydrochloride

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- emerging
  Claim: Registry of 63 cases of pyridoxine-dependent and -responsive seizures standing
- resolved
Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry.
Basura GJ, Hagland SP, Wiltse AM, Gospe SM
pmid 18762976
- established
  Claim: Sensory neuropathy from high-dose pyridoxine (case series) standing
- resolved
Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome.
Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D, Brown MJ
pmid 6308447

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

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