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Peptide Atlas · Vitamin

Pyridoxine hydrochloride

High daily doses of pyridoxine (vitamin B6) caused ataxia and severe sensory neuropathy in seven adults, all of whom improved after stopping it.

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Summary

High daily doses of pyridoxine (vitamin B6) caused ataxia and severe sensory neuropathy in seven adults, all of whom improved after stopping it. · pmid:6308447

Pyridoxine-dependent seizures are a rare disorder in which seizures, usually beginning in newborns, respond to pyridoxine; in a registry of 63 North American cases, 47 were seizure-free on pyridoxine alone. · pmid:18762976

Identity

IUPAC name: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride. · pubchem:6019

PubChem CID 6019: Pyridoxine Hydrochloride, C8H12ClNO3, 205.64 g/mol. · pubchem:6019

CAS registry number 58-56-0. · pubchem:6019

Where the evidence actually sits

Established50%
Emerging50%

Proportion of the 2 claims about Pyridoxine hydrochloride standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. (1983) · establishedClinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry. (2009) · emerging19832009

2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Pyridoxine hydrochloride yet.

Dose evidence, rung by rung

A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.

  1. Approved-label dose · a resolved regulatory document names a labelled dose

    nothing resolved on this rung

  2. Studied human doses · resolved human studies at the established tier
    • Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. · pmid 6308447 · 1983
  3. Observational evidence · resolved human data at the emerging tier: thin, or contested
    • Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry. · pmid 18762976 · 2009
  4. Community-reported protocols · protocol propositions from distinct members, counted once per human

    nothing resolved on this rung

  5. Preclinical evidence · resolved animal, cell or mechanistic work

    nothing resolved on this rung

2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.