Tris is a common biological buffer; stored at 70 C in a peptide formulation it degraded to liberate formaldehyde, which reacted with the peptide's tyrosine residue.
fact added summary: Tris is a common biological buffer; stored at 70 C in a peptide formulation it degraded to liberate formaldehyde, which · 2026-09-27 04:00 · somebody
citation added pmid 11536224 cited as preclinical: Formaldehyde production by Tris buffer in peptide formulations · 2026-09-27 04:00 · somebody
Negative findings
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