Peptide Atlas · Excipient

Tris HCl

Tris is a common biological buffer; stored at 70 C in a peptide formulation it degraded to liberate formaldehyde, which reacted with the peptide's tyrosine residue.

preclinical

provisional
PubChem 93573
1 citation
0 discussions
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Tris
Tris(hydroxymethyl)aminomethane hydrochloride

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 1 citation resolves to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Formaldehyde production by Tris buffer in peptide formulations standing
- resolved
Formaldehyde production by Tris buffer in peptide formulations at elevated temperature.
Song Y, Schowen RL, Borchardt RT, Topp EM
pmid 11536224

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Negative findings

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