Peptide Atlas · Vitamin

Ascorbic acid

In the LOVIT trial of 872 adults with sepsis on vasopressors, intravenous vitamin C raised the risk of death or persistent organ dysfunction at 28 days compared with placebo (44.5% against 38.5%).

established

provisional
PubChem 54670067
2 citations
0 discussions
0 followers
Ascorbate
L-ascorbic acid
L-xyloascorbic acid
Vitamin C

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What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Ascorbic acid. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Vitamin C pharmacokinetics: oral versus intravenous plasma concentrations	established	pmid 15068981
Intravenous vitamin C increased death or organ dysfunction in sepsis (LOVIT RCT)	established	pmid 35704292

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.