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Peptide Atlas · Vitamin

Ascorbic acid

In the LOVIT trial of 872 adults with sepsis on vasopressors, intravenous vitamin C raised the risk of death or persistent organ dysfunction at 28 days compared with placebo (44.5% against 38.5%).

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

    • established
      Claim: Vitamin C pharmacokinetics: oral versus intravenous plasma concentrations standing
    • resolved

    Vitamin C pharmacokinetics: implications for oral and intravenous use.

    Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M

    pmid 15068981

    • established
      Claim: Intravenous vitamin C increased death or organ dysfunction in sepsis (LOVIT RCT) standing
    • resolved

    Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.

    Lamontagne F, Masse MH, Menard J, Sprague S, Pinto R, Heyland DK, Cook DJ, Battista MC, Day AG, Guyatt GH, Kanji S, Parke R, McGuinness SP, Tirupakuzhi Vijayaraghavan BK, Annane D, Cohen D, Arabi YM, Bolduc B, Marinoff N, Rochwerg B, Millen T, Meade MO, Hand L, Watpool I, Porteous R, Young PJ, D'Aragon F, Belley-Cote EP, Carbonneau E, Clarke F, Maslove DM, Hunt M, Chassé M, Lebrasseur M, Lauzier F, Mehta S, Quiroz-Martinez H, Rewa OG, Charbonney E, Seely AJE, Kutsogiannis DJ, LeBlanc R, Mekontso-Dessap A, Mele TS, Turgeon AF, Wood G, Kohli SS, Shahin J, Twardowski P, Adhikari NKJ, LOVIT Investigators and the Canadian Critical Care Trials Group

    pmid 35704292

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

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