In the LOVIT trial of 872 adults with sepsis on vasopressors, intravenous vitamin C raised the risk of death or persistent organ dysfunction at 28 days compared with placebo (44.5% against 38.5%).
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
In the LOVIT trial of 872 adults with sepsis on vasopressors, intravenous vitamin C raised the risk of death or persistent organ dysfunction at 28 days compared with placebo (44.5% against 38.5%). · pmid:35704292
Mechanism
Plasma vitamin C is tightly controlled when it is taken by mouth: 1.25 g orally gave peak plasma levels of about 135 micromol/L against about 885 micromol/L intravenously, and modelling predicted a 60-fold gap at the highest doses. · pmid:15068981
Proportion of the 2 claims about Ascorbic acid standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Ascorbic acid yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Vitamin C pharmacokinetics: implications for oral and intravenous use. · pmid 15068981 · 2004
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. · pmid 35704292 · 2022
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.