Peptide Atlas · Vitamin

Cholecalciferol (Vitamin D3)

In a five-year randomized, double-blind trial in 2,686 people aged 65 to 85, oral vitamin D3 (100,000 IU every four months) reduced first fractures at the hip, wrist, forearm or spine by a third compared with placebo.

established

provisional
PubChem 5280795
2 citations
0 discussions
0 followers
Activated 7-dehydrocholesterol
Calciol
Colecalciferol
Vitamin D3

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

established — replicated in humans, or settled by a regulator

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Cholecalciferol (Vitamin D3). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Four-monthly oral vitamin D3 reduced osteoporotic fractures in older people (RCT, n=2686)	established	pmid 12609940
Vitamin D3 raises serum 25(OH)D more than vitamin D2 (meta-analysis)	established	pmid 22552031

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.