In a five-year randomized, double-blind trial in 2,686 people aged 65 to 85, oral vitamin D3 (100,000 IU every four months) reduced first fractures at the hip, wrist, forearm or spine by a third compared with placebo.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
In a five-year randomized, double-blind trial in 2,686 people aged 65 to 85, oral vitamin D3 (100,000 IU every four months) reduced first fractures at the hip, wrist, forearm or spine by a third compared with placebo. · pmid:12609940
A meta-analysis of randomized trials found vitamin D3 more effective than vitamin D2 at raising serum 25-hydroxyvitamin D, especially when given as a bolus. · pmid:22552031
Proportion of the 2 claims about Cholecalciferol (Vitamin D3) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Cholecalciferol (Vitamin D3) yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. · pmid 12609940 · 2003
Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. · pmid 22552031 · 2012
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.