Colivelin is a hybrid peptide made by fusing activity-dependent neurotrophic factor (ADNF) to a potent humanin derivative; it blocked neuronal death caused by Alzheimer's-related genes and amyloid-beta at 100 femtomolar in cell studies.
fact added identity: CAS registry number 867021-83-8. · 2026-09-27 12:04 · somebody
fact added summary: Colivelin is a hybrid peptide made by fusing activity-dependent neurotrophic factor (ADNF) to a potent humanin derivativ · 2026-09-27 12:04 · somebody
fact added mechanism: Given intranasally to mouse models of Alzheimer's disease, colivelin reached the brain through the olfactory bulb and le · 2026-09-27 12:04 · somebody
citation added pmid 16267233 cited as preclinical: Colivelin (ADNF fused to a humanin derivative) is neuroprotective at femtomolar concentrations · 2026-09-27 12:04 · somebody