Colivelin is a hybrid peptide made by fusing activity-dependent neurotrophic factor (ADNF) to a potent humanin derivative; it blocked neuronal death caused by Alzheimer's-related genes and amyloid-beta at 100 femtomolar in cell studies.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Colivelin is a hybrid peptide made by fusing activity-dependent neurotrophic factor (ADNF) to a potent humanin derivative; it blocked neuronal death caused by Alzheimer's-related genes and amyloid-beta at 100 femtomolar in cell studies. · pmid:16267233
Mechanism
Given intranasally to mouse models of Alzheimer's disease, colivelin reached the brain through the olfactory bulb and lessened memory impairment, with increased STAT3 phosphorylation in the septohippocampal region. · pmid:17928813
Proportion of the 2 claims about Colivelin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Colivelin yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. · pmid 16267233 · 2005
Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease. · pmid 17928813 · 2008
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.