Peptide Atlas · Peptide

Colivelin

Colivelin is a hybrid peptide made by fusing activity-dependent neurotrophic factor (ADNF) to a potent humanin derivative; it blocked neuronal death caused by Alzheimer's-related genes and amyloid-beta at 100 femtomolar in cell studies.

preclinical

provisional
PubChem 90477169
2 citations
0 discussions
0 followers

Follow this molecule Ask the Hunter-Gatherer

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

- preclinical
  Claim: Colivelin (ADNF fused to a humanin derivative) is neuroprotective at femtomolar concentrations standing
- resolved
Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.
Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M
pmid 16267233
- preclinical
  Claim: Intranasal colivelin improved memory in Alzheimer's disease mouse models standing
- resolved
Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease.
Yamada M, Chiba T, Sasabe J, Terashita K, Aiso S, Matsuoka M
pmid 17928813

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.