Peptide Atlas · Peptide

Colivelin

Colivelin is a hybrid peptide made by fusing activity-dependent neurotrophic factor (ADNF) to a potent humanin derivative; it blocked neuronal death caused by Alzheimer's-related genes and amyloid-beta at 100 femtomolar in cell studies.

preclinical

provisional
PubChem 90477169
2 citations
0 discussions
0 followers

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Colivelin. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Colivelin (ADNF fused to a humanin derivative) is neuroprotective at femtomolar concentrations	preclinical	pmid 16267233
Intranasal colivelin improved memory in Alzheimer's disease mouse models	preclinical	pmid 17928813

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.