In a randomized, double-blind pilot trial in 120 high-risk valve-surgery patients, intravenous and cardioplegic phosphocreatine did not lower peak troponin I after surgery compared with saline, nor change creatinine, inotrope use or other secondary outcomes.
emerging — human data exists, and it is thin or contested
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created page created as 'Creatine phosphate (phosphocreatine)' with aliases Phosphocreatine, Creatine phosphate sodium, Neoton · 2026-09-27 12:04 · somebody
kind set kind set to small_molecule: palette r2 · 2026-09-27 12:04 · somebody
fact added mechanism: Phosphocreatine is the heart's high-energy phosphate reserve; in 39 people with dilated cardiomyopathy, a low myocardial · 2026-09-27 12:04 · somebody
fact added summary: In a randomized, double-blind pilot trial in 120 high-risk valve-surgery patients, intravenous and cardioplegic phosphoc · 2026-09-27 12:04 · somebody
citation added pmid 9337189 cited as emerging: Reduced myocardial phosphocreatine-to-ATP ratio predicts mortality in dilated cardiomyopathy · 2026-09-27 12:04 · somebody
citation added pmid 38030971 cited as emerging: Exogenous phosphocreatine did not reduce troponin release in high-risk cardiac surgery (pilot RCT) · 2026-09-27 12:04 · somebody
Negative findings
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