In a randomized, double-blind pilot trial in 120 high-risk valve-surgery patients, intravenous and cardioplegic phosphocreatine did not lower peak troponin I after surgery compared with saline, nor change creatinine, inotrope use or other secondary outcomes.
emerging — human data exists, and it is thin or contested
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
In a randomized, double-blind pilot trial in 120 high-risk valve-surgery patients, intravenous and cardioplegic phosphocreatine did not lower peak troponin I after surgery compared with saline, nor change creatinine, inotrope use or other secondary outcomes. · pmid:38030971
Mechanism
Phosphocreatine is the heart's high-energy phosphate reserve; in 39 people with dilated cardiomyopathy, a low myocardial phosphocreatine-to-ATP ratio measured by phosphorus MR spectroscopy predicted higher mortality over 2.5 years. · pmid:9337189
Proportion of the 2 claims about Creatine phosphate (phosphocreatine) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Creatine phosphate (phosphocreatine) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
Myocardial protection with phosphocreatine in high-risk cardiac surgery patients: a randomized trial. · pmid 38030971 · 2023
Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. · pmid 9337189 · 1997
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.