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Peptide Atlas · Small molecule

Creatine phosphate (phosphocreatine)

In a randomized, double-blind pilot trial in 120 high-risk valve-surgery patients, intravenous and cardioplegic phosphocreatine did not lower peak troponin I after surgery compared with saline, nor change creatinine, inotrope use or other secondary outcomes.

What the evidence says

six tiers, never blended

emerging — human data exists, and it is thin or contested

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Creatine phosphate (phosphocreatine). Tier reflects study design, not enthusiasm.
ClaimTierSource
Exogenous phosphocreatine did not reduce troponin release in high-risk cardiac surgery (pilot RCT)emergingpmid 38030971
Reduced myocardial phosphocreatine-to-ATP ratio predicts mortality in dilated cardiomyopathyemergingpmid 9337189

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.