In a dose-finding trial in 120 older people with mild vitamin B12 deficiency, oral cyanocobalamin normalised the deficiency marker methylmalonic acid only at about 650 to 1,000 micrograms a day, over 200 times the recommended dietary allowance.
fact added identity: CAS registry number 68-19-9. · 2026-09-27 12:04 · somebody
fact added summary: In a dose-finding trial in 120 older people with mild vitamin B12 deficiency, oral cyanocobalamin normalised the deficie · 2026-09-27 12:04 · somebody
fact added summary: In ten patients with pernicious anemia, oral crystalline cyanocobalamin (1,000 micrograms a day for three months) raised · 2026-09-27 12:04 · somebody
citation added pmid 15911731 cited as established: Oral cyanocobalamin dose needed to correct mild B12 deficiency in older people (RCT, n=120) · 2026-09-27 12:04 · somebody
citation added pmid 24672108 cited as emerging: Oral cyanocobalamin in pernicious anemia (open-label, n=10) · 2026-09-27 12:04 · somebody
Negative findings
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