In a dose-finding trial in 120 older people with mild vitamin B12 deficiency, oral cyanocobalamin normalised the deficiency marker methylmalonic acid only at about 650 to 1,000 micrograms a day, over 200 times the recommended dietary allowance.
established — replicated in humans, or settled by a regulator
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
In a dose-finding trial in 120 older people with mild vitamin B12 deficiency, oral cyanocobalamin normalised the deficiency marker methylmalonic acid only at about 650 to 1,000 micrograms a day, over 200 times the recommended dietary allowance. · pmid:15911731
In ten patients with pernicious anemia, oral crystalline cyanocobalamin (1,000 micrograms a day for three months) raised serum cobalamin and hemoglobin in most of them. · pmid:24672108
Proportion of the 2 claims about Cyanocobalamin standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Cyanocobalamin yet.
Dose evidence, rung by rung
A studied human dose exists on file. Open the rung: the dose is the paper's, in its context, never PepJunkie's.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. · pmid 15911731 · 2005
Observational evidence· resolved human data at the emerging tier: thin, or contested
Effects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients. · pmid 24672108 · 2005
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
nothing resolved on this rung
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.