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Peptide Atlas · Peptide

Dihexa

Dihexa is an analogue of the brain peptide angiotensin IV that can be given orally and crosses the blood-brain barrier.

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

  • created page created as 'Dihexa' with aliases PNB-0408, N-hexanoyl-Tyr-Ile-(6)-aminohexanoic amide · 2026-09-27 04:00 · somebody
  • kind set kind set to peptide: palette r1 · 2026-09-27 04:00 · somebody
  • fact added identity: PubChem CID 129010512: N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide, C27H44N4O5, 504.7 g/mol. · 2026-09-27 04:00 · somebody
  • fact added identity: CAS registry number 1401708-83-5. · 2026-09-27 04:00 · somebody
  • fact added identity: IUPAC name: (2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentan · 2026-09-27 04:00 · somebody
  • fact added summary: Dihexa is an analogue of the brain peptide angiotensin IV that can be given orally and crosses the blood-brain barrier. · 2026-09-27 04:00 · somebody
  • fact added history: The 2014 paper proposing that dihexa works by binding hepatocyte growth factor and activating the c-Met system was retra · 2026-09-27 04:00 · somebody
  • fact added history: A 2012 paper developing angiotensin IV analogues as hepatocyte growth factor/Met modifiers was also retracted in 2025. · 2026-09-27 04:00 · somebody
  • fact added mechanism: In APP/PS1 Alzheimer's model mice, dihexa restored spatial learning in the Morris water maze and activated PI3K/AKT sign · 2026-09-27 04:00 · somebody
  • citation added pmid 34827486 cited as preclinical: Dihexa in APP/PS1 mice: memory recovery via PI3K/AKT · 2026-09-27 04:00 · somebody
  • citation added pmid 40312093 cited as unknown: Retraction notice: the 2014 HGF/c-Met mechanism paper · 2026-09-27 04:00 · somebody
  • citation added pmid 40312092 cited as unknown: Retraction notice: the 2012 angiotensin IV analogue development paper · 2026-09-27 04:00 · somebody
  • question added With the HGF/c-Met papers retracted, what independent evidence remains for dihexa's mechanism? · 2026-09-27 04:00 · somebody

Negative findings

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