Peptide Atlas · Peptide

Dihexa

Dihexa is an analogue of the brain peptide angiotensin IV that can be given orally and crosses the blood-brain barrier.

preclinical

provisional
PubChem 129010512
3 citations
0 discussions
0 followers
N-hexanoyl-Tyr-Ile-(6)-aminohexanoic amide
PNB-0408

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Dihexa. Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Dihexa in APP/PS1 mice: memory recovery via PI3K/AKT	preclinical	pmid 34827486
Retraction notice: the 2012 angiotensin IV analogue development paper	unknown	pmid 40312092
Retraction notice: the 2014 HGF/c-Met mechanism paper	unknown	pmid 40312093

Unanswered questions

With the HGF/c-Met papers retracted, what independent evidence remains for dihexa's mechanism? open

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.