Dihexa

Summary

Dihexa is an analogue of the brain peptide angiotensin IV that can be given orally and crosses the blood-brain barrier. · pmid:34827486

Mechanism

In APP/PS1 Alzheimer's model mice, dihexa restored spatial learning in the Morris water maze and activated PI3K/AKT signalling. · pmid:34827486

History

The 2014 paper proposing that dihexa works by binding hepatocyte growth factor and activating the c-Met system was retracted by The Journal of Pharmacology and Experimental Therapeutics in 2025. · pmid:40312093

A 2012 paper developing angiotensin IV analogues as hepatocyte growth factor/Met modifiers was also retracted in 2025. · pmid:40312092

Identity

PubChem CID 129010512: N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide, C27H44N4O5, 504.7 g/mol. · pubchem:129010512

CAS registry number 1401708-83-5. · pubchem:129010512

IUPAC name: (2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide. · pubchem:129010512

Where the evidence actually sits

Proportion of the 3 claims about Dihexa standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.

Living evidence history

3 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.

Structure

No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Dihexa yet.

Dose evidence, rung by rung

No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.

1. Approved-label dose · a resolved regulatory document names a labelled dose

   nothing resolved on this rung

2. Studied human doses · resolved human studies at the established tier

   nothing resolved on this rung

3. Observational evidence · resolved human data at the emerging tier: thin, or contested

   nothing resolved on this rung

4. Community-reported protocols · protocol propositions from distinct members, counted once per human

   nothing resolved on this rung

5. Preclinical evidence · resolved animal, cell or mechanistic work
   • AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway. · pmid 34827486 · 2021

3 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.