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Peptide Atlas · Peptide

Dihexa

Dihexa is an analogue of the brain peptide angiotensin IV that can be given orally and crosses the blood-brain barrier.

What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 3 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

    • preclinical
      Claim: Dihexa in APP/PS1 mice: memory recovery via PI3K/AKT standing
    • resolved

    AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.

    Sun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y

    pmid 34827486

    • unknown
      Claim: Retraction notice: the 2012 angiotensin IV analogue development paper standing
    • resolved

    Retraction notice to "Development of Angiotensin IV Analogs as Hepatocyte Growth Factor/Met Modifiers" [J Pharmacol Exp Ther 340 (2012) 539-548].

    Kawas LH, McCoy AT, Yamamoto BJ, Wright JW, Harding JW

    pmid 40312092

    • unknown
      Claim: Retraction notice: the 2014 HGF/c-Met mechanism paper standing
    • resolved

    Retraction notice to "The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System" [J Pharmacol Exp Ther 351 (2014) 390-402].

    Benoist CC, Kawas LH, Zhu M, Tyson KA, Stillmaker L, Appleyard SM, Wright JW, Wayman GA, Harding JW

    pmid 40312093

A claim's standing is its latest row in an append-only history; a tombstone names the later evidence and the reason. The Graveyard and the Resurrection Yard.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.