Peptide Atlas · Cofactor

Dihydrolipoic acid (DHLA, reduced ALA)

Dihydrolipoic acid is the reduced form of alpha-lipoic acid; together the two form a redox couple with a low redox potential of -0.32 V, which makes dihydrolipoic acid a strong reductant.

preclinical

provisional
PubChem 421
2 citations
0 discussions
0 followers
6,8-dimercaptooctanoic acid
DHLA
dihydrothioctic acid
reduced lipoic acid

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What the evidence says

six tiers, never blended

preclinical — animal, cell or mechanistic work — not yet about people

every claim resolves to its source

All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.

Evidence, kept apart

The Atlas never mixes evidence types into one blob. Each claim below carries the tier it actually sits in; an unresolved citation is shown and does not move the page.

Evidence map for Dihydrolipoic acid (DHLA, reduced ALA). Tier reflects study design, not enthusiasm.
Claim	Tier	Source
Antioxidant and pro-oxidant activities of alpha-lipoic and dihydrolipoic acid	preclinical	pmid 12127266
Dihydrolipoic acid scavenges peroxyl radicals and reduces ascorbyl radicals in model systems	preclinical	pmid 1417985

Unanswered questions

No open questions on file. Either everything about this molecule is known, or nobody has admitted what is not.

Negative findings

failure is information

Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.