Dihydrolipoic acid is the reduced form of alpha-lipoic acid; together the two form a redox couple with a low redox potential of -0.32 V, which makes dihydrolipoic acid a strong reductant.
preclinical — animal, cell or mechanistic work — not yet about people
every claim resolves to its source
All 2 citations resolve to their original source. · 0 posts naming it, 0 members counted once each.
Summary
Dihydrolipoic acid is the reduced form of alpha-lipoic acid; together the two form a redox couple with a low redox potential of -0.32 V, which makes dihydrolipoic acid a strong reductant. · pmid:12127266
Mechanism
In simple oxidation systems, dihydrolipoic acid, but not lipoic acid itself, directly scavenged peroxyl radicals in water and in membranes and reduced the ascorbyl radical of vitamin C. · pmid:1417985
Laboratory studies also show pro-oxidant effects: dihydrolipoic acid stimulated superoxide production in rat liver mitochondria. · pmid:12127266
Proportion of the 2 claims about Dihydrolipoic acid (DHLA, reduced ALA) standing at each tier. Community volume is shown on the Consensus tab beside this and is never averaged into it.
Living evidence history
2 resolved citations, oldest to newest, coloured by tier. Retractions and contradictions land here as they are recorded.
Structure
No structure representation on record. PepJunkie draws only what an authoritative record supplies; for a peptide that is the residue sequence, and none has been curated for Dihydrolipoic acid (DHLA, reduced ALA) yet.
Dose evidence, rung by rung
No established safe human dose. Nothing on file establishes one. That is a statement about the evidence PepJunkie holds, not a promise about the molecule.
Approved-label dose· a resolved regulatory document names a labelled dose
nothing resolved on this rung
Studied human doses· resolved human studies at the established tier
nothing resolved on this rung
Observational evidence· resolved human data at the emerging tier: thin, or contested
nothing resolved on this rung
Community-reported protocols· protocol propositions from distinct members, counted once per human
nothing resolved on this rung
Preclinical evidence· resolved animal, cell or mechanistic work
Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. · pmid 12127266 · 2002
Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. · pmid 1417985 · 1992
2 resolved citations, 0 unresolved (an unresolved citation lends nothing). Community volume is its own rung and is never averaged into the evidence rungs.
Negative findings
failure is information
Nobody has filed a failure yet. Failures are information; this list is waiting for an honest one.